1(2H)-isoquinolinone, 5-hydroxy-

Name	5-hydroxyisoquinolin-1(2H)-one
Synonyms	1,5-ISOQUINOLINEDIOL Isoquinoline-1,5-diol 5-HYDROXYISOCARBOSTYRIL 1,5-DIHYDROXYISOQUINOLINE 1,5-Dihydroxyisoquinoline -HYDROXY-1(2H)-ISOQUINOLINE 5-HYDROXY-1(2H)-ISOQUINOLINE 5-hydroxyisoquinolin-1(2H)-one 5-Hydroxyisoquinolin-1(2H)-one 5-HYDROXY-1(2H)-ISOQUINOLINONE 5-Hydroxyisoquinoline-1(2H)-one 1(2H)-isoquinolinone, 5-hydroxy- 1,5-ISOQUINOLINEDIOL(1,5-DIHYDROXYISOQUI NO-LINE) 1,5-Dihydroxyisoquinoline, 5-Hydroxy-1(2H)-isoquinolinone, DiQ
CAS	5154-02-9
EINECS	637-104-6
InChI	InChI=1/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5,11H,(H,10,12)

Molecular Formula	C9H7NO2
Molar Mass	161.16
Density	1.2480 (rough estimate)
Melting Point	270-275 °C
Boling Point	287.44°C (rough estimate)
Flash Point	234.3°C
Solubility	DMSO: >36mg/mL
Vapor Presure	3.18E-09mmHg at 25°C
Appearance	solid
Color	off-white
pKa	8.52±0.20(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.5050 (estimate)
In vitro study	1,5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene. 1,5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina. 1,5-Isoquinolinediol (500 μM H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1 expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of retinal nitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase in the retina.

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
HS Code	29337900

Biological activity	1,5-Isoquinolinediol is an effective PARP inhibitor with an IC50 value of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetic-induced oxidative stress induced by retinal NADPH oxidase.
target	PARP 0.18-0.37 μM (IC 50 )
in vitro research	1,5-isoquinolinediol heads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene. 1,5-isoquinolinediol is a potent antagonist and decreases cleaved PARP in diabetic retina. 1,5-Isoquinolinediol (500 μM H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1 expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of retinal nitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase in the retina.

Last Update：2024-04-10 22:29:15

Product Name: 1,5-Isoquinolinediol Visit Supplier Webpage Request for quotation
CAS: 5154-02-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: 1,5-Isoquinolinediol Visit Supplier Webpage Request for quotation
CAS: 5154-02-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

1(2H)-isoquinolinone, 5-hydroxy-

1(2H)-isoquinolinone, 5-hydroxy- Request for Quotation